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For Catholic and (later) Protestant civilizations, an election for Holy Roman Emperor is called every 25 turns, and the Holy Roman Emperor is voted upon by all Catholic and Protestant civilizations and city-states, awarding 250 VP to the winner and a bonus in production on their Trade Routes with city-states. In addition, there are three institutional sources of VP: the Holy Roman Empire, the Caliphate, and the Ecumenical Patriarchy. The Holy City for Islam begins as a City-State, but the Holy Cities for Catholicism and Orthodoxy belong to the Papal States and Byzantium, respectively, giving these civilizations an advantage. Civilizations can gain victory points by controlling their State Religion's Holy City and/or Jerusalem. Apart from attaining victory points normally, there are also several methods to acquire additional points. The winner of the scenario is whichever civilization has the most victory points after 250 turns. All religions except Romuva and the Heresies begin fully enhanced. Finally, Judaism may also spread throughout your cities.
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With the exception of Romuva, each of these religions has an associated heresy - Catharism (Catholicism), Bogomilism (Orthodoxy), Druze (Islam), and Reformed (Protestantism) - which can spread throughout your empire when your Piety gets low. In addition, Protestantism will be founded in the City-State of Saxony late in the game and will begin to deal massive damage in particular to the Catholic civilization's religion, whilst Hussitism can be founded in the City-State of Bohemia. Your relationships with other civilizations can be helped or hindered depending on whether or not that civilization follows your State Religion. There are four playable State Religions in the scenario: Roman Catholicism, Eastern Orthodoxy, Islam, and Romuva, whose Holy Cities are Rome, Constantinople, Mecca, and Vilnius, respectively. The scenario is based on religion in medieval times in which you must "Grow your medieval kingdom into one of the great nations of Renaissance Europe, fending off outside invasions from Mongols and Ottoman Turks and fighting the religious wars of the Crusades and Reformation!"